Age-related dysregulation of intestinal epithelium fucosylation is linked to an increased risk of colon cancer.

ABSTRACT: Colon cancer affects people of all ages. However, its frequency, as well as the related morbidity and mortality, are high among older adults. The complex physiological changes in the aging gut substantially limit the development of cancer therapies. Here, we identify a potentially unique intestinal microenvironment that is linked with an increased risk of colon cancer in older adults. Our findings show that aging markedly influenced persistent fucosylation of the apical surfaces of intestinal epithelial cells, which resulted in a favorable environment for tumor growth. Furthermore, our findings shed light on the importance of the host-commensal interaction, which facilitates the dysregulation of fucosylation and promotes tumor growth as people get older. We analyzed colonic microbial popul

SUBMITTER: Wang Z 

PROVIDER: S-EPMC10972600 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature