The difference in endothelium-dependent relaxation components in proximal and distal thoracic aorta regions of male rats.

ABSTRACT: Aorta, the largest vessel in the body, is generally considered anatomically homogeneous, yet spatial functional differences exist. In our study, we conducted a comprehensive analysis by reexamining public RNA-SEQ data, comparing expression patterns between thoracic and abdominal aorta. Additionally, we measured acetylcholine-induced relaxations of the different regions of thoracic aorta in Wistar Rats. Our results revealed a distinct percentage difference in acetylcholine-induced relaxation in the proximal and distal segments of the thoracic aorta (p = 1.14e-4). To explain this variation, we performed differential expression analysis of previously published RNA-sequencing data between thoracic and abdominal aorta, which showed 497 differentially expressed genes between these locations. Fro

SUBMITTER: Mezhenskyi OR 

PROVIDER: S-EPMC10972677 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature