Background Selection From Unlinked Sites Causes Nonindependent Evolution of Deleterious Mutations.

ABSTRACT: Background selection describes the reduction in neutral diversity caused by selection against deleterious alleles at other loci. It is typically assumed that the purging of deleterious alleles affects linked neutral variants, and indeed simulations typically only treat a genomic window. However, background selection at unlinked loci also depresses neutral diversity. In agreement with previous analytical approximations, in our simulations of a human-like genome with a realistically high genome-wide deleterious mutation rate, the effects of unlinked background selection exceed those of linked background selection. Background selection reduces neutral genetic diversity by a factor that is independent of census population size. Outside of genic regions, the strength of background selection inc

SUBMITTER: Matheson J 

PROVIDER: S-EPMC10972689 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature