The hagfish genome and the evolution of vertebrates.

ABSTRACT: As the only surviving lineages of jawless fishes, hagfishes and lampreys provide a crucial window into early vertebrate evolution^1-3. Here we investigate the complex history, timing and functional role of genome-wide duplications^4-7 and programmed DNA elimination^8,9 in vertebrates in the light of a chromosome-scale genome sequence for the brown hagfish Eptatretus atami. Combining evidence from syntenic and phylogenetic analyses, we establish a comprehensive picture of vertebrate genome evolution, including an auto-tetraploidization (1R_V) that predates the early Cambrian cyclostome-gnathostome split, followed by a mid-late Cambrian allo-tetraploidization (2R_JV) in gnathostomes and a prolonged Cambrian-Ordovician hexaploidization (2R

SUBMITTER: Marletaz F 

PROVIDER: S-EPMC10972751 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature