Ultrasound remission after biologic induction and long-term endoscopic remission in Crohn's disease: a prospective cohort study.

ABSTRACT:

Background

The Bowel Ultrasound Score (BUSS) accurately detects therapy-related changes by using the Simple Endoscopic Score for Crohn's disease (SES-CD) as the reference standard. We aimed to evaluate ultrasound remission as a treatment target and its prediction for long-term endoscopic remission.

Methods

This single-centre prospective observational study, based at a tertiary referral centre in Milan, Italy, enrolled, between March 1, 2018, and January 31, 2021, adult patients with active CD (SES-CD >2) who were starting biologics. Colonoscopy and IUS was performed at baseline and at 12 months (mean 12.8 ± 4.2). The primary outcome was the predictive value of ultrasound remission at week 12 (BUSS ≤3.52) for long-term endoscopic remission at 12 months. The International Bowe

SUBMITTER: Allocca M 

PROVIDER: S-EPMC10972812 | biostudies-literature | 2024 May

REPOSITORIES: biostudies-literature