Pharmacokinetic Analysis of [¹⁸F]FES PET in the Human Brain and Pituitary Gland.

ABSTRACT:

Purpose

Estrogen receptors (ER) are implicated in psychiatric disorders. We assessed if ER availability in the human brain could be quantified using 16α-[¹⁸F]-fluoro-17β-estradiol ([¹⁸F]FES) positron emission tomography (PET).

Procedures

Seven post‑menopausal women underwent a dynamic [¹⁸F]FES PET scan with arterial blood sampling. A T1-weighted MRI was acquired for anatomical information. After one week, four subjects received a selective ER degrader (SERD), four hours before the PET scan. Pharmacokinetic analysis was performed using a metabolite-corrected plasma curve as the input function. The optimal kinetic model was selected based on the Akaike information criterion and standard error of estimated parameters. Accuracy of Logan graphical

SUBMITTER: Ghazanfari N 

PROVIDER: S-EPMC10972926 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature