Rs4862705 in the melatonin receptor 1A gene is associated with renal function decline in type 1 diabetes individuals.

ABSTRACT:

Aim

The pathogenesis of chronic diabetes complications has oxidative stress as one of the major elements, and single-nucleotide polymorphisms (SNPs) in genes belonging to antioxidant pathways modulate susceptibility to these complications. Considering that melatonin is a powerful antioxidant compound, our aim was to explore, in a longitudinal cohort study of type 1 diabetes (T1D) individuals, the association of microvascular complications and SNPs in the gene encoding melatonin receptor 1A (MTNR1A).

Methods

Eight SNPs in MTNR1A were genotyped in 489 T1D individuals. Besides cross-sectional analyses of SNPs with each one of the microvascular complications (distal polyneuropathy, cardiovascular autonomic neuropathy, retinopathy, and diabetic kidney disease), a lo

SUBMITTER: Daher G 

PROVIDER: S-EPMC10972958 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature