Mechanical convergence in mixed populations of mammalian epithelial cells.

ABSTRACT: Tissues consist of cells with different molecular and/or mechanical properties. Measuring the forces and stresses in mixed-cell populations is essential for understanding the mechanisms by which tissue development, homeostasis, and disease emerge from the cooperation of distinct cell types. However, many previous studies have primarily focused their mechanical measurements on dissociated cells or aggregates of a single-cell type, leaving the mechanics of mixed-cell populations largely unexplored. In the present study, we aimed to elucidate the influence of interactions between different cell types on cell mechanics by conducting in situ mechanical measurements on a monolayer of mammalian epithelial cells. Our findings revealed that while individual cell types displayed varying magnitudes o

SUBMITTER: Gauquelin E 

PROVIDER: S-EPMC10973031 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature