Mathematical modeling in autoimmune diseases: from theory to clinical application.

ABSTRACT: The research & development (R&D) of novel therapeutic agents for the treatment of autoimmune diseases is challenged by highly complex pathogenesis and multiple etiologies of these conditions. The number of targeted therapies available on the market is limited, whereas the prevalence of autoimmune conditions in the global population continues to rise. Mathematical modeling of biological systems is an essential tool which may be applied in support of decision-making across R&D drug programs to improve the probability of success in the development of novel medicines. Over the past decades, multiple models of autoimmune diseases have been developed. Models differ in the spectra of quantitative data used in their development and mathematical methods, as well as in the level of "mechanistic gran

SUBMITTER: Ugolkov Y 

PROVIDER: S-EPMC10973044 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature