Increasing age of multiple sclerosis onset from 1920 to 2022: a population-based study.

ABSTRACT:

Objective

To study the age at onset of relapsing-remitting multiple sclerosis (RRMS) during the past century.

Methods

This is a population-based cohort study of persons diagnosed with RRMS in Hordaland, Møre, and Romsdal counties, Western Norway, from 1920 to 2022. Individual patient data were available and assessed from previously conducted prevalence and incidence studies in addition to hospital records up until October 31, 2022. Participants were categorized according to onset period and analyzed for temporal trends in age at onset, time from onset to diagnosis, and distribution of onset over time.

Results

We identified 3364 persons with confirmed RRMS. The mean age at onset significantly increased (p < 0.001) throughout the study period, despite a decrease in time

SUBMITTER: Habbestad A 

PROVIDER: S-EPMC10973050 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature