The adaptor protein 2 (AP2) complex modulates habituation and behavioral selection across multiple pathways and time windows.

ABSTRACT: Animals constantly integrate sensory information with prior experience to select behavioral responses appropriate to the current situation. Genetic factors supporting this behavioral flexibility are often disrupted in neuropsychiatric conditions, such as the autism-linked ap2s1 gene which supports acoustically evoked habituation learning. ap2s1 encodes an AP2 endocytosis adaptor complex subunit, although its behavioral mechanisms and importance have been unclear. Here, we show that multiple AP2 subunits regulate acoustically evoked behavior selection and habituation learning in zebrafish. Furthermore, ap2s1 biases escape behavior choice in sensory modality-specific manners, and broadly regulates action selection across sensory contexts. We demonstrate that the AP2 comp

SUBMITTER: Zuniga Mouret R 

PROVIDER: S-EPMC10973200 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature