Intrinsic functional connectivity strength of SuperAgers in the default mode and salience networks: Insights from ADNI.

ABSTRACT: There exists a group of older individuals who appear to be resistant to age-related memory decline. These "SuperAgers" have been shown to demonstrate preservation of cortical thickness and functional connectivity strength across the cortex which positively correlates with memory performance. Over the last decade, roughly 30 articles have been published regarding SuperAgers; however, to our knowledge, no replications of these studies have been published. The current study sought to conceptually replicate Zhang and colleagues' (2020) findings that SuperAgers demonstrate stronger intrinsic functional connectivity within the default mode (DMN) and salience networks (SN), and that connectivity strength within these networks correlates with memory performance. We identified 20 SuperAgers and 20

SUBMITTER: Keenan HE 

PROVIDER: S-EPMC10973202 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature