Gut barrier dysfunction and the risk of ICU-acquired bacteremia- a case-control study.

ABSTRACT:

Background

Impaired intestinal barrier function can enable passage of enteric microorganisms into the bloodstream and lead to nosocomial bloodstream infections during critical illness. We aimed to determine the relative importance of gut translocation as a source for ICU-acquired enterococcal bacteremia of unknown origin.

Methods

We conducted a nested case-control study in two mixed medical-surgical tertiary ICUs in the Netherlands among patients enrolled between 2011 and 2018. We selected 72 cases with ICU-acquired bacteremia due to enterococci (which are known gastrointestinal tract commensals) and 137 matched controls with bacteremia due to coagulase-negative staphylococci (CoNS) (which are of non-intestinal origin). We measured intestinal fatty acid-binding protein, tref

SUBMITTER: Varkila MRJ 

PROVIDER: S-EPMC10973289 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature