Association of lower extremity peripheral arterial disease with quantitative muscle features from computed tomography angiography.

ABSTRACT:

Objectives

To explore the association between lower extremity muscle features from CTA and peripheral arterial disease (PAD) severity using digital subtraction angiography (DSA) as reference standard.

Methods

Informed consent was waived for this Institutional Review Board approved retrospective study. PAD patients were recruited from July 2016 to September 2020. Two radiologists evaluated PAD severity on DSA and CTA using runoff score. The patients were divided into two groups: mild PAD (DSA score ≤ 7) vs. severe PAD (DSA score > 7). After segmenting lower extremity muscles from CTA, 95 features were extracted for univariable analysis, logistic regression model (LRM) analysis, and sub-dataset analysis (PAD prediction based on only part of the images). AUC of CTA score and LR

SUBMITTER: Hu G 

PROVIDER: S-EPMC10973322 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature