Development of a formula for estimated glomerular filtration rate in pregnant women from physiological hyperfiltration of serum creatinine.

ABSTRACT: Increased body fluids during pregnancy complicates the application of estimated glomerular filtration rate (eGFR) formulas that are based on body surface area. Furthermore, gestational renal dysfunction cannot be identified if the serum creatinine (SCr) concentration is within the non-pregnant reference interval (RI) despite inadequate pregnancy-related renal hyperfiltration. 1484 SCr measurements from 957 healthy pregnant women were collected. The average SCr value of gestational week (GW) 0-3 was the representative SCr value of non-pregnant status. While the distribution of SCr measurements varied across GWs, it was transformed into a normal distribution using the bootstrap resampling method. A polynomial linear regression method was applied to achieve a continuous and smooth transformat

SUBMITTER: Ahn K 

PROVIDER: S-EPMC10973345 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature