Urate-lowering therapy is associated with a reduced risk of arrhythmias: a systematic review and meta-analysis.

ABSTRACT:

Objective

While urate-lowering therapy (ULT) is linked to increased cardioprotective benefits on primary prevention of cardiovascular events such myocardial infarction or heart failure, little is known regarding their effects on arrhythmia risk. The purpose of this study was to investigate the relationship between incident arrhythmias and ULT.

Methods

We searched MEDLINE and Embase from inception to May 2023. Included studies were randomized controlled trials and cohort studies that compared the risk of cardiac arrhythmias among ULT users with non-ULT users.

Results

A total of 12,420 patients from five studies were analyzed, comprising 7,359 subjects in the ULT group and 5,061 subjects in the non-ULT group. Our results showed that ULT users had significant reductions

SUBMITTER: Waitayangkoon P 

PROVIDER: S-EPMC10973354 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature