Clinical outcomes of interstitial lung abnormalities: a systematic review and meta-analysis.

ABSTRACT: Interstitial lung abnormalities (ILA), incidental findings on computed tomography scans, have raised concerns due to their association with worse clinical outcomes. Our meta-analysis, which included studies up to April 2023 from PubMed/MEDLINE, Embase, and Cochrane Library, aimed to clarify the impact of ILA on mortality, lung cancer development, and complications from lung cancer treatments. Risk ratios (RR) with 95% confidence intervals (CI) were calculated for outcomes. Analyzing 10 studies on ILA prognosis and 9 on cancer treatment complications, we found that ILA significantly increases the risk of overall mortality (RR 2.62, 95% CI 1.94-3.54; I² = 90%) and lung cancer development (RR 3.85, 95% CI 2.64-5.62; I² = 22%). Additionally, cancer patients with ILA had h

SUBMITTER: Seok J 

PROVIDER: S-EPMC10973382 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature