Factors impacting antibody kinetics, including fever and vaccination intervals, in SARS-CoV-2-naive adults receiving the first four mRNA COVID-19 vaccine doses.

ABSTRACT: To evaluate the antibody response following the initial four doses of mRNA vaccines (BNT162b2 or mRNA-1273) in SARS-CoV-2-naïve healthy adults and investigate factors influencing antibody titer increases, this prospective cohort study was conducted in Japan from March 2021. The study included participants who received either the 1st and 2nd doses (n = 467), 3rd dose (n = 157), or 4th dose (n = 89). Blood samples were collected before and up to 6 months after each dose, and anti-receptor-binding domain antibody levels were measured. Multivariate analysis (usin multiple linear regression or linear mixed models) revealed several factors significantly associated with higher post-vaccination antibody levels, including mRNA-1273 vaccine (after the 1st and 2nd dose), male gender (after the 3rd an

SUBMITTER: Matsuura T 

PROVIDER: S-EPMC10973463 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature