Multi-organ single-cell transcriptomics of immune cells uncovered organ-specific gene expression and functions.

ABSTRACT: Despite the wealth of publicly available single-cell datasets, our understanding of distinct resident immune cells and their unique features in diverse human organs remains limited. To address this, we compiled a meta-analysis dataset of 114,275 CD45+ immune cells sourced from 14 organs in healthy donors. While the transcriptome of immune cells remains relatively consistent across organs, our analysis has unveiled organ-specific gene expression differences (GTPX3 in kidney, DNTT and ACVR2B in thymus). These alterations are linked to different transcriptional factor activities and pathways including metabolism. TNF-α signaling through the NFkB pathway was found in several organs and immune compartments. The presence of distinct expression profiles for NFkB family genes and their target gene

SUBMITTER: Tsagiopoulou M 

PROVIDER: S-EPMC10973478 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature