S100A8/A9 as a prognostic biomarker with causal effects for post-acute myocardial infarction heart failure.

ABSTRACT: Heart failure is the prevalent complication of acute myocardial infarction. We aim to identify a biomarker for heart failure post-acute myocardial infarction. This observational study includes 1062 and 1043 patients with acute myocardial infarction in the discovery and validation cohorts, respectively. The outcomes are in-hospital and long-term heart failure events. S100A8/A9 is screened out through proteomic analysis, and elevated circulating S100A8/A9 is independently associated with heart failure in discovery and validation cohorts. Furthermore, the predictive value of S100A8/A9 is superior to the traditional biomarkers, and the addition of S100A8/A9 improves the risk estimation using traditional risk factors. We finally report causal effect of S100A8/A9 on heart failure in three indepe

SUBMITTER: Ma J 

PROVIDER: S-EPMC10973499 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature