Schnurri-3 controls osteogenic fate of Adipoq-lineage progenitors in bone marrow.

ABSTRACT:

Background

Recently, the osteogenic potential of Adiponectin-labeled adipogenic lineage progenitors (Adipoq-lineage progenitors) in bone marrow has been observed to support bone maintenance and repair. However, little is known about the function of Schnurri-3 (SHN3, also known as HIVEP3) in other mesenchymal lineage cells, apart from its negative regulation of bone formation on osteoblasts.

Method

In this study, we used single-cell RNA sequencing (scRNA-seq) profiling to demonstrate that Adipoq-lineage progenitors express higher levels of Shn3 compared to other mesenchymal cell populations in mice and humans. To investigate the role of SHN3 in Adipoq-lineage progenitors, we generated a murine model specifically harboring a Shn3-deficient allele in Adipoq-expressing ce

SUBMITTER: Li Z 

PROVIDER: S-EPMC10973536 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature