Desipramine induces anti-inflammatory dorsal root ganglion transcriptional signatures in the murine spared nerve injury model.

ABSTRACT: Monoamine-targeting antidepressants serve as frontline medications for chronic pain and associated comorbidities. While persistent anti-allodynic properties of antidepressants generally require weeks of treatment, several groups have demonstrated acute analgesic effects within hours of administration, suggesting a role in non-mesocorticolimbic pain processing regions such as the peripheral nervous system. To further explore this possibility, after four weeks of spared nerve injury or sham surgeries, we systemically administered desipramine or saline for an additional three weeks and performed whole transcriptome RNA sequencing on L3-6 dorsal root ganglia. Along with alterations in molecular pathways associated with neuronal activity, we observed a robust immunomodulatory transcriptional si

SUBMITTER: Serafini RA 

PROVIDER: S-EPMC10973649 | biostudies-literature | 2024 Jan-Jun

REPOSITORIES: biostudies-literature