Periodontitis and Outer Retinal Thickness: a Cross-Sectional Analysis of the United Kingdom Biobank Cohort.

ABSTRACT:

Purpose

Periodontitis, a ubiquitous severe gum disease affecting the teeth and surrounding alveolar bone, can heighten systemic inflammation. We investigated the association between very severe periodontitis and early biomarkers of age-related macular degeneration (AMD), in individuals with no eye disease.

Design

Cross-sectional analysis of the prospective community-based cohort United Kingdom (UK) Biobank.

Participants

Sixty-seven thousand three hundred eleven UK residents aged 40 to 70 years recruited between 2006 and 2010 underwent retinal imaging.

Methods

Macular-centered OCT images acquired at the baseline visit were segmented for retinal sublayer thicknesses. Very severe periodontitis was ascertained through a touchscreen questionnaire. Linear mixed effec

SUBMITTER: Wagner SK 

PROVIDER: S-EPMC10973663 | biostudies-literature | 2024 Jul-Aug

REPOSITORIES: biostudies-literature