A Noninvasive Clinical Method to Measure in Vivo Mechanical Strains of the Lamina Cribrosa by OCT.

ABSTRACT:

Objective

To measure mechanical strain of the lamina cribrosa (LC) after intraocular pressure (IOP) change produced 1 week after a change in glaucoma medication.

Design

Cohort study.

Participants

Adult glaucoma patients (23 eyes, 15 patients) prescribed a change in IOP-lowering medication.

Intervention

Noninvasive OCT imaging of the eye.

Main outcome measures

Deformation calculated by digital volume correlation of OCT scans of the LC before and after IOP lowering by medication.

Results

Among 23 eyes, 17 eyes of 12 persons had IOP lowering ≥ 3 mmHg (reduced IOP group) with tensile anterior-posterior E_zz strain = 1.0% ± 1.1% (P = 0.003) and compressive radial strain (E_rr) = -0.3% ± 0.5% (P<

SUBMITTER: Hannay V 

PROVIDER: S-EPMC10973664 | biostudies-literature | 2024 Jul-Aug

REPOSITORIES: biostudies-literature