Mycophenolate and azathioprine efficacy in interstitial lung disease: a systematic review and meta-analysis.

ABSTRACT:

Objectives

Mycophenolate mofetil (MMF) and azathioprine (AZA) are immunomodulatory treatments in interstitial lung disease (ILD). This systematic review aimed to evaluate the efficacy of MMF or AZA on pulmonary function in ILD.

Design

Population included any ILD diagnosis, intervention included MMF or AZA treatment, outcome was delta change from baseline in per cent predicted forced vital capacity (%FVC) and gas transfer (diffusion lung capacity of carbon monoxide, %DLco). The primary endpoint compared outcomes relative to placebo comparator, the secondary endpoint assessed outcomes in treated groups only.

Eligibility criteria

Randomised controlled trials (RCTs) and prospective observational studies were included. No language restrictions were applied. Retrospective s

SUBMITTER: Lombardi F 

PROVIDER: S-EPMC10973691 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature