Serum heme oxygenase-1 level predicts clinical outcome after acute ischemic stroke.

ABSTRACT:

Aims

The relationship between heme oxygenase-1 (HO-1) and human ischemic stroke outcome remains unclear, which was investigated in this study.

Methods

Acute ischemic stroke patients admitted within 24 h were enrolled. Serum HO-1 levels at baseline were measured via ELISA. Poor 3-month functional outcome was defined as modified Rankin Scale (mRS) score 3-6. Multivariable-adjusted binary logistic regression and restricted cubic spline models were employed to examine association between serum HO-1 and functional outcome. HO-1's additive prognostic utility was assessed by net reclassification index (NRI) and integrated discrimination improvement (IDI).

Results

Of 194 eligible patients, 79 (40.7%) developed poor functional outcomes at 3-month follow-up. The highest quartil

SUBMITTER: Wang H 

PROVIDER: S-EPMC10973699 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature