Reduction in Postprandial Peak Glucose With Increased Technosphere Insulin Dosage.

ABSTRACT:

Background

Technosphere Insulin (TI) is an ultra-rapid-acting inhaled insulin. This study assessed the mean peak two-hour postprandial glucose concentration with the initial TI dose (dose 1) calculated per the current label (United State Prescribing Information) compared with a ~2× higher dose (dose 2). Secondary objectives were to evaluate hypoglycemia within the two-hour postprandial period, evaluate change in forced expiratory volume in one second (FEV₁) before and after the two-hour postprandial period, and monitor for other adverse events.

Methods

Twenty patients with diabetes, on basal-bolus insulin therapy, received an initial dose 1 of TI followed by the higher dose 2, one to three days later. Subjects received an identical meal for both visits, and TI dos

SUBMITTER: Kaiserman KB 

PROVIDER: S-EPMC10973860 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature