Ortho-C-H methoxylation of aryl halides enabled by a polarity-reversed N-O reagent.

ABSTRACT: Oxygen-substituted arenes widely exist in biologically important molecules and can serve as versatile handles to install other functional groups. However, direct and site-selective installation of oxygen groups to common aromatic compounds remains challenging, especially when additional arene functionalization is simultaneously required. Current arene C-H oxidation strategies generally require directing groups or precisely prefunctionalized substrates to control site-selectivity. While palladium/norbornene cooperative catalysis is promising for site-specific arene vicinal difunctionalization through simultaneous reactions with an electrophile and a nucleophile, the electrophile scope has been limited to species based on relatively 'soft' elements, such as carbon, nitrogen and sulfur. Here

SUBMITTER: Liu X 

PROVIDER: S-EPMC10973943 | biostudies-literature | 2023 Oct

REPOSITORIES: biostudies-literature