Inhibition of Aflatoxin Production in <i>Aspergillus flavus</i> by a <i>Klebsiella</i> sp. and Its Metabolite Cyclo(l-Ala-Gly).

ABSTRACT: During an experiment where we were cultivating aflatoxigenic Aspergillus flavus on peanuts, we accidentally discovered that a bacterium adhering to the peanut strongly inhibited aflatoxin (AF) production by A. flavus. The bacterium, isolated and identified as Klebsiella aerogenes, was found to produce an AF production inhibitor. Cyclo(l-Ala-Gly), isolated from the bacterial culture supernatant, was the main active component. The aflatoxin production-inhibitory activity of cyclo(l-Ala-Gly) has not been reported. Cyclo(l-Ala-Gly) inhibited AF production in A. flavus without affecting its fungal growth in a liquid medium with stronger potency than cyclo(l-Ala-l-Pro). Cyclo(l-Ala-Gly) has the strongest AF production-inhibitory activity among known AF production-inhi

SUBMITTER: Sakuda S 

PROVIDER: S-EPMC10973989 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature