Advances of Recombinant Adenoviral Vectors in Preclinical and Clinical Applications.

ABSTRACT: Adenoviruses (Ad) have the potential to induce severe infections in vulnerable patient groups. Therefore, understanding Ad biology and antiviral processes is important to comprehend the signaling cascades during an infection and to initiate appropriate diagnostic and therapeutic interventions. In addition, Ad vector-based vaccines have revealed significant potential in generating robust immune protection and recombinant Ad vectors facilitate efficient gene transfer to treat genetic diseases and are used as oncolytic viruses to treat cancer. Continuous improvements in gene delivery capacity, coupled with advancements in production methods, have enabled widespread application in cancer therapy, vaccine development, and gene therapy on a large scale. This review provides a comprehensive overv

SUBMITTER: Scarsella L 

PROVIDER: S-EPMC10974029 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature