Study on Varicella-Zoster Virus Antibody Levels among Children Aged 1-7 Years in Changzhou, China.

ABSTRACT: We aim to understand the varicella-zoster virus (VZV) antibody levels in children after vaccination and to construct VZV-IgG centile curves and reference values for children aged 1-7 years. From September to October 2023, a total of 806 children were recruited according to the time intervals of 1 month, 6 months, 1 year, 2 years, and 3 years after vaccination, as well as age groups. A generalized additive model for location, shape, and scale (GAMLSS) was applied to estimate P₃, P₁₀, P₂₅, P₅₀, P₇₅, P₉₀, and P₉₇ centile reference values of VZV-IgG, and 95% reference intervals were calculated. A total of 785 children were included in the analysis, with an overall positivity rate of 70.3%, a median antibody concentrat

SUBMITTER: Wu D 

PROVIDER: S-EPMC10974081 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature