Acute Toxicity Assessment of Orally Administered Microplastic Particles in Adult Male Wistar Rats.

ABSTRACT: While the effects of chronic exposure to microplastic particles (MPs) are extensively studied, the outcomes of a single treatment have received relatively less attention. To investigate MPs' potential acute toxicity, including their impact on general health status (victual consumption, sensorimotor deficits, and clinical toxicity signs) and serum biochemical parameters (markers of organ/tissue function and oxidative stress indicators), we administered thoroughly characterized MPs (1.4, 35, or 125 mg/kg), generated from polyethylene terephthalate (PET) bottles, to adult male Wistar rats via oral gavage. The MPs' short-term effects were assessed with well-established tests and methods. The results point to the absence of sensorimotor deficits and clinical toxicity signs, while levels of mark

SUBMITTER: Gusevac Stojanovic I 

PROVIDER: S-EPMC10974097 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature