Pertussis Vaccines Scarcely Provide Protection against Bordetella parapertussis Infection in Children-A Systematic Review and Meta-Analysis.

ABSTRACT:

Background

Pertussis, or whooping cough, is a global public health concern. Pertussis vaccines have demonstrated good protection against Bordetella pertussis infections, but their effectiveness against Bordetella parapertussis remains debated due to conflicting study outcomes.

Methods

A systematic review and meta-analysis were conducted to assess the effectiveness of pertussis vaccines in protecting children against B. parapertussis infection. A comprehensive search of PubMed, Web of Science, and Scopus databases was conducted, and randomized controlled trials (RCTs) and observational studies that met inclusion criteria were included in the analysis.

Results

The meta-analysis, involving 46,533 participants, revealed no significant protective effec

SUBMITTER: Remesh AT 

PROVIDER: S-EPMC10974608 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature