Targeting the receptor tyrosine kinase MerTK shows therapeutic value in gastric adenocarcinoma.

ABSTRACT:

Background

Despite multiple therapeutic modalities, the overall survival of patients with gastric adenocarcinoma remains poor, especially for advanced tumor stages. Although the tyrosine kinase MerTK has shown therapeutic relevance in several tumor entities, its potential effects in gastric adenocarcinoma have not yet been sufficiently characterized.

Methods

MerTK expression and its influence on patient survival were evaluated by immunohistochemistry in a cohort of 140 patients with gastric adenocarcinoma. CRISPR/Cas9 knockout and siRNA knockdown of MerTK in the gastric cancer cell lines SNU1, SNU5, and MKN45 was used to analyze protein expression, growth, migration, and invasion properties in vitro and in a murine xenograft model. MerTK was pharmacologically targeted with t

SUBMITTER: Wirsik NM 

PROVIDER: S-EPMC10974716 | biostudies-literature | 2024 Apr

REPOSITORIES: biostudies-literature