Investigation of the Association between Air Pollution and Non-Alcoholic Fatty Liver Disease in the European Population: A Mendelian Randomization Study.

ABSTRACT: Non-alcoholic fatty liver disease (NAFLD) is currently the most prevalent chronic liver disease worldwide. At the same time, the relationship between air pollution and the likelihood of developing NAFLD has been a subject of debate due to conflicting findings in previous observational research. Our objective was to examine the potential correlation between air pollutant levels and the risk of NAFLD in the European population by employing a two-sample Mendelian randomization (MR) analysis. The UK Biobank Consortium provided the summary statistics for various air pollution indicators (PM_2.5, PM_2.5 absorbance, PM_2.5-10, PM₁₀, NO₂, and NO_x). Additionally, information on NAFLD was obtained from three studies, including one deriva

SUBMITTER: Yang J 

PROVIDER: S-EPMC10974773 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature