NLC-Based Sunscreen Formulations with Optimized Proportion of Encapsulated and Free Filters Exhibit Enhanced UVA and UVB Photoprotection.

ABSTRACT: The topical use of sunscreens is recommended for avoiding the damaging effects of UV radiation. However, improvements are still needed in the existing products to enhance their photoprotection effectiveness and safety. This involves minimizing the use of chemical UV filters while providing enhanced and prolonged photoprotection. This work investigated novel sunscreen formulations and their UV protection effects by encapsulating Uvinul^® A, Tinosorb^® S, and Uvinul^® T150 into nanostructured lipid carriers (NLCs) based on bacuri butter and raspberry seed oil. First, the impact of critical formulation and process parameters on NLCs' particle size was evaluated using a 2² Face Centered Central Composite Design. Then, formulations were evaluated in term

SUBMITTER: de Araujo MM 

PROVIDER: S-EPMC10974804 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature