Genomic Insights into <i>Staphylococcus aureus</i> Isolates Exhibiting Diminished Daptomycin Susceptibility.

ABSTRACT: Daptomycin is one of the last therapeutic resources for multidrug-resistant gram-positive bacteria. Despite its structural similarities with glycopeptides, its mechanisms of action and resistance are different and in some respects are not completely understood. Mutations in several genes have been associated with daptomycin resistance, especially in mprF, walkR, rpoB and rpoC, but their role and importance remain to be elucidated. We have studied mutations in 11 genes, which have been previously associated with daptomycin non-susceptibility, in nine daptomycin-non-susceptible Staphylococcus aureus clinical isolates (daptomycin MIC: >1 mg/L). Susceptibility to daptomycin, vancomycin, linezolid, oxacillin, telavancin and dalbavancin was studied. walkR

SUBMITTER: Gomez-Casanova N 

PROVIDER: S-EPMC10974884 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature