Potential Serological Misdiagnosis of Barmah Forest Virus and Ross River Virus Diseases as Chikungunya Virus Infections in Australia: Comparison of ELISA with Neutralization Assay Results.

ABSTRACT: To evaluate the frequency of errors in the diagnosis of medical laboratory-diagnosed Chikungunya virus (CHIKV) infections in Australia, we studied 42 laboratory-diagnosed CHIKV serum samples from one Queensland medical laboratory by ELISA IgG/IgM and measured the specific neutralization antibodies (Nab) against Barmah Forest virus (BFV), CHIKV and Ross River virus (RRV). The sero-positivity rates for the sera were as follows: anti-BFV IgG⁺ 19% (8/42), IgM⁺ 2.4% (1/42) and Nab⁺ 16.7% (7/42); anti-CHIKV IgG⁺ 90.5% (38/42), IgM⁺ 21.4% (9/42) and Nab⁺ 90.5% (38/42); anti-RRV IgG⁺ 88.1% (37/42), IgM⁺ 28.6% (12/42) and Nab⁺ 83.2% (35/42), respectively. Among the samples with multiple antibody posit

SUBMITTER: Kizu J 

PROVIDER: S-EPMC10974935 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature