Liquid Chromatography ICP-MS to Assess the Stability of ¹⁷⁵Lu- and ^natGa-Based Tumor-Targeting Agents towards the Development of ¹⁷⁷Lu- and ⁶⁸Ga-Labeled Radiopharmaceuticals.

ABSTRACT: In recent years, nuclear medicine has gained great interest, partly due to the success story of [¹⁷⁷Lu]Lu-PSMA-617 (Pluvicto^TM). Still, in-depth preclinical characterization of radiopharmaceuticals mainly happens at centers that allow working with radioactive material. To support the development of novel radiopharmaceuticals, alternative non-radioactive characterization assays are highly desirable. The aim of this study was to demonstrate that inductively coupled plasma mass spectrometry (ICP-MS) associated with a chromatographic system can serve as a surrogate for the classical high-performance liquid chromatography (HPLC)-radiodetector combination for preclinical in vitro characterization of non-radioactive metal-labeled analogs of radiopharmaceuticals. In this proo

SUBMITTER: Wallimann RH 

PROVIDER: S-EPMC10974936 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature