Categorical Analysis of Database Consistency in Reporting Drug-Drug Interactions for Cardiovascular Diseases.

ABSTRACT: Drug-drug interactions (DDIs) can either enhance or diminish the positive or negative effects of the associated drugs. Multiple drug combinations create difficulties in identifying clinically relevant drug interactions; this is why electronic drug interaction checkers frequently report DDI results inconsistently. Our paper aims to analyze drug interactions in cardiovascular diseases by selecting drugs from pharmacotherapeutic subcategories of interest according to Level 2 of the Anatomical Therapeutic Chemical (ATC) classification system. We checked DDIs between 9316 pairs of cardiovascular drugs and 25,893 pairs of cardiovascular and other drugs. We then evaluated the overall agreement on DDI severity results between two electronic drug interaction checkers. Thus, we obtained a fair ag

SUBMITTER: Suciu L 

PROVIDER: S-EPMC10975099 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature