Enhanced Skin Permeation of 5-Fluorouracil through Drug-in-Adhesive Topical Patches.

ABSTRACT: 5-fluorouracil (5-FU), commercially available as a topical product, is approved for non-melanoma skin cancer (NMSC) treatment with several clinical limitations. This work aimed to develop 5-FU-loaded topical patches as a potential alternative to overcome such drawbacks. The patches offer accurate dosing, controlled drug release and improved patient compliance. Our study highlights the development of Eudragit^® E (EuE)-based drug-in-adhesive (DIA) patches containing a clinically significant high level of 5-FU (approximately 450 µg/cm²) formulated with various chemical permeation enhancers. The patches containing Transcutol^® (Patch-TRAN) or oleic acid (Patch-OA) demonstrated significantly higher skin penetration ex vivo than their control counterpart, reaching

SUBMITTER: Kim S 

PROVIDER: S-EPMC10975131 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature