Exploring the Gut Microbiome and Metabolome in Individuals with Alopecia Areata Disease.

ABSTRACT: In recent years, heightened attention has been devoted to unravelling the intricate interplay between genetic and environmental factors shaping the gut microbiota and its significance for human health. This study delves into exploring the plausible connection between Alopecia Areata (AA), an autoimmune disease, and the dynamics of the gut microbiome. Examining a cohort of healthy adults and individuals with AA, both the gut microbiota composition and volatile organic compound (VOC) metabolites from faeces and urine were analysed. While overall microbiota composition showed no significant differences, intra-individual variability revealed distinctions related to age, gender, and pathology status, with AA individuals exhibiting reduced species richness and evenness. Differential abundance an

SUBMITTER: Nikoloudaki O 

PROVIDER: S-EPMC10975414 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature