Mesoporous Silica as an Alternative Vehicle to Overcome Solubility Limitations.

ABSTRACT: Toxicological studies are a part of the drug development process and the preclinical stages, for which suitable vehicles ensuring easy and safe administration are crucial. However, poor aqueous solubility of drugs complicates vehicle screening for oral administration since non-aqueous solvents are often not tolerable. In the case of the anti-infective corallopyronin A, currently undergoing preclinical investigation for filarial nematode and bacterial infections, commonly used vehicles such as polyethylene glycol 200, aqueous solutions combined with cosolvents or solubilizers, or aqueous suspension have failed due to insufficient tolerability, solubility, or the generation of a non-homogeneous suspension. To this end, the aim of the study was to establish an alternative approach which offer

SUBMITTER: Becker T 

PROVIDER: S-EPMC10975448 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature