Diversity and Molecular Evolution of Antimicrobial Peptides in Caecilian Amphibians.

ABSTRACT: Antimicrobial peptides (AMPs) are key molecules in the innate immune defence of vertebrates with rapid action, broad antimicrobial spectrum, and ability to evade pathogen resistance mechanisms. To date, amphibians are the major group of vertebrates from which most AMPs have been characterised, but most studies have focused on the bioactive skin secretions of anurans (frogs and toads). In this study, we have analysed the complete genomes and/or transcriptomes of eight species of caecilian amphibians (order Gymnophiona) and characterised the diversity, molecular evolution, and antimicrobial potential of the AMP repertoire of this order of amphibians. We have identified 477 candidate AMPs within the studied caecilian genome and transcriptome datasets. These candidates are grouped into 29 AMP

SUBMITTER: Benitez-Prian M 

PROVIDER: S-EPMC10975883 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature