Designing a Placebo Microneedle Stamp: Modeling and Validation in a Clinical Control Trial.

ABSTRACT: Recently, several clinical studies have been conducted using microneedles (MNs), and various devices have been developed. This study aimed to propose and confirm the feasibility of a placebo control for activating MN clinical research. A 0.5 mm MN stamp with 42 needles was used as a treatment intervention, and a placebo stamp with four acupressure-type needles that did not penetrate was proposed and designed as a control for comparison. First, to check whether the placebo stamp did not invade the skin and to set an appropriate level of pressure to be provided during skin stimulation, two participants were stimulated with five different forces on the forearm, and then the skin was dyed. Secondly, to evaluate the validity of the placebo control group, a blinded study between the MN and place

SUBMITTER: Jeong SY 

PROVIDER: S-EPMC10975904 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature