Novel Universal Recombinant Rotavirus A Vaccine Candidate: Evaluation of Immunological Properties.

ABSTRACT: Rotavirus infection is a leading cause of severe dehydrating gastroenteritis in children under 5 years of age. Although rotavirus-associated mortality has decreased considerably because of the introduction of the worldwide rotavirus vaccination, the global burden of rotavirus-associated gastroenteritis remains high. Current vaccines have a number of disadvantages; therefore, there is a need for innovative approaches in rotavirus vaccine development. In the current study, a universal recombinant rotavirus antigen (URRA) for a novel recombinant vaccine candidate against rotavirus A was obtained and characterised. This antigen included sequences of the VP8* subunit of rotavirus spike protein VP4. For the URRA, for the first time, two approaches were implemented simultaneously-the application

SUBMITTER: Granovskiy DL 

PROVIDER: S-EPMC10976063 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature