Cognitive training of mice attenuates age-related decline in associative learning and behavioral flexibility.

ABSTRACT: Identifying factors that influence age-related cognitive decline is crucial, given its severe personal and societal impacts. However, studying aging in human or animal models is challenging due to the significant variability in aging processes among individuals. Additionally, longitudinal and cross-sectional studies often produce differing results. In this context, home-cage-based behavioral analysis over lifespans has emerged as a significant method in recent years. This study aimed to explore how prior experience affects cognitive performance in mice of various age groups (4, 12, and 22 months) using a home-cage-based touchscreen test battery. In this automated system, group-housed, ID-chipped mice primarily obtain their food during task performance throughout the day, motivated by their

SUBMITTER: Attalla D 

PROVIDER: S-EPMC10976437 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature