Clickable X-ray Nanoprobes for Nanoscopic Bioimaging of Cellular Structures.

ABSTRACT: Synchrotron-based X-ray microscopy (XRM) has garnered widespread attention from researchers due to its high spatial resolution and excellent energy (element) resolution. Existing molecular probes suitable for XRM include immune probes and genetic labeling probes, enabling the precise imaging of various biological targets within cells. However, immune labeling techniques are prone to cross-interference between antigens and antibodies. Genetic labeling technologies have limited systems that allow express markers independently, and moreover, genetically encoded labels based on catalytic polymerization lack a fixed morphology. When applied to cell imaging, this can result in reduced localization accuracy due to the diffusion of labels within the cells. Therefore, both techniques face challenge

SUBMITTER: Tang Q 

PROVIDER: S-EPMC10976567 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature