Peptidoglycan-Targeted [¹⁸F]3,3,3-Trifluoro-d-alanine Tracer for Imaging Bacterial Infection.

ABSTRACT: Imaging is increasingly used to detect and monitor bacterial infection. Both anatomic (X-rays, computed tomography, ultrasound, and MRI) and nuclear medicine ([¹¹¹In]-WBC SPECT, [¹⁸F]FDG PET) techniques are used in clinical practice but lack specificity for the causative microorganisms themselves. To meet this challenge, many groups have developed imaging methods that target pathogen-specific metabolism, including PET tracers integrated into the bacterial cell wall. We have previously reported the d-amino acid derived PET radiotracers d-methyl-[¹¹C]-methionine, d-[3-¹¹C]-alanine, and d-[3-¹¹C]-alanine-d-alanine, which showed robust bacterial accumulation in vitro and in vivo. Given the clinical importance of radionuclide

SUBMITTER: Sorlin AM 

PROVIDER: S-EPMC10976610 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature