AxoDetect: an automated nerve image segmentation and quantification workflow for computational nerve modeling.

ABSTRACT: Objective.Bioelectronic treatments targeting near-organ innervation have unprecedented clinical applications. Particularly in the spleen, the inhibition of the cholinergic inflammatory response by near-organ nerve stimulation has potential to replace pharmacological treatments in chronic and autoimmune diseases. A caveat is that the optimization of therapeutic stimulation parameters relies onin vivoexperimentation, which becomes challenging due to the small nerve diameters (2 μm), complex anatomy, and mixed axon type composition of the autonomic nerves. Effective development ofin silicomodels requires tools which allow for fast and efficient quantification of axonal composition of specific nerves. Current approaches to generate such information rely on manual image seg

SUBMITTER: Lloyd DA 

PROVIDER: S-EPMC10976901 | biostudies-literature | 2024 Mar

REPOSITORIES: biostudies-literature